Emerging research into underappreciated aspects of cholesterol biochemistry has revealed that levels of cholesterol account for only a portion of the cardiovascular risk profile, while the properties of the molecules responsible for transporting cholesterol through the blood, called lipoproteins, offer important insights into the development of atherosclerosis.
In fact, the size and density of lipoproteins are important factors for cardiovascular risk – for example, large, buoyant LDL (“bad cholesterol”) particles are much less dangerous than small, dense LDL particles; likewise large, buoyant HDL (“good cholesterol”) particles offer greater vascular protection than smaller, more dense HDL. The development of advanced lipid testing strategies that take the importance of lipoprotein particle size into consideration, such as the NMR (nuclear magnetic resonance) test, allows a far deeper assessment of cardiovascular risk than a conventional lipid profile utilized by most mainstream medical practitioners.
Furthermore, metabolic processes, such as oxidation and glycation, modify the functionality of lipoproteins, transforming them from cholesterol transport vehicles into highly reactive molecules capable of damaging the delicate endothelial cells that line our arterial walls. This endothelial damage both initiates and promotes atherogenesis. Scientifically supported natural interventions can target the formation of these modified lipoproteins and help avert deadly cardiovascular diseases such as heart attack and stroke.
The pharmaceutical industry has been very successful in promoting cholesterol reduction with statin drugs as essentially the most important strategy for reducing cardiovascular risk. However, although the use of pharmaceutical treatment has saved lives, Life Extension has long recognized that optimal cardiovascular protection involves a multifactorial strategy that includes at least 17 different factors responsible for vascular disease.
Life Extension believes that innovative strategies for decreasing vascular risk should incorporate thoroughcholesterol and lipoprotein testing, as well as strategic nutrient and pharmaceutical intervention, for optimal health effects and vascular support.
- The Blood Lipids: Cholesterol and Triglycerides
- Lipoproteins: Blood Lipid Transporters
- Blood Lipids and Lipoproteins and Disease Risk
- The Multifactorial Pathology of Vascular Disease
- Blood Lipid Measurement
- Conventional Approaches to Managing Blood Lipids and Lipoproteins
- Nutritional Approaches to Managing Blood Lipids and Lipoproteins
- Replacing Lost Hormones to Achieve Optimal Cholesterol Levels
- Nutrients for Lipid Management
- Inhibiting Cholesterol Synthesis
- Inhibiting Absorption of Dietary Cholesterol
- Inhibiting Oxidation and Glycation of LDL
- Enhancing Cholesterol Elimination
- Optimizing the Lipid Profile